Microbiology and Molecular Biology of AOM caused by Pneumococci .PI: Michael E. Pichichero, MD. Investigator-Initiated Research Agreement Pfizer Vaccine Research. 05/01/09 – 12/31/15.

Phase 4, Post marketing Study Evaluating the Impact of Prevnar 13 (13-Valent Pneumococcal Conjugate Vaccine, 13vPnC) in Reducing Acute Otitis Media and Nasopharyngeal Colonization Caused by vaccine Serotypes of Streptococcus pneumoniae in Healthy Children. PI: Michael E. Pichichero, MD- Sponsor Pfizer Vaccine Research. 10/1/10-12/31/15

Infant Mouse Models of Pneumococcal Colonization and Pneumonia, seeking a correlate of protection. PI: Michael E. Pichichero, MD- Sponsor: Sanofi Pasteur. 1/1/11-12/31/13.

NTHi Immunity in Young Children. PI: Michael E, Pichichero, MD. NIH, NIDCD, RO-1008671, 3/1/12-2/28/17

Pneumococcal protein recombinant vaccine (PPrV) correlates of protection.. PI: Michael E. Pichichero, MD. Sponsor: Sanofi Pasteur. 1/1/13-12/31/16.

Immune Potentiation to Improve Neonatal and Pediatric Vaccines. PI: Naveen Surendran, Michael Pichichero MD. NIH, R03 AI117700. 5/1/15-4/30/17.

Immunogenicity of Moraxella catarrhalis vaccine candidates in children. PI: Dabin Ren, Michael E Pichichero MD. NIH, R03 AI113649. 5/4/15-6/30/17.

Determinants of Streptococcus pneumoniae (Spn) pathogenesis during viral co-infections: comparative studies in infant and adult mice. PI: M. Nadeem Khan. Sponsor: Merck. 10/1/15-9/30/16.

Evaluation of PCV15 vaccine efficacy against Streptococcus pneumonia nasopharyngeal commensal carriage and invasive spn pathogenesis in adult and infant mice. PI: M. Nadeem Khan. Sponsor: Merck. 10/1/16-9/30/17.

Identification of protective epitopes of Streptococcus pneumoniae protein vaccine candidates against pneumococcal diseases. PI: Qingfu Xu. Sponsor: Merck. 11/23/15-11/22/16.

Comparative analysis of inflammatory responses and bacterial virulence gene expressions induced by non-pathogenic and pathogenic strains of Streptococcus pneumonia stereotype 22F causing acute otitis media. PI: Qingfu Xu. Sponsor: Merck. 11/23/16-11/22/17.

A Study Evaluating Acute Otitis Media and Nasopharyngeal Colonization caused by Streptococcus pneumonia in Healthy Children. PI: Michael E. Pichichero, MD (Investigator-Initiated). Sponsor: Sanofi Pasteur 1/1/15-6/30/19. Molecular Analysis of Pathogens in Otitis Media by PCR. PI: Ravinder Kaur. Sponsor: Drexel University. 01/01/16-03/31/18. Microbiome and Virome of Children. PI: Michael E. Pichichero, MD. (Investigator-Initiated). Sponsor: Merck. 12/1/18-12/31/19.

Serum antibody levels to pneumococcal polysaccharides 22F, 33F, 19A and 6A (PCV15 components) that correlate with protection from acute otitis media in children. CI: Michael E Pichichero: Merck. 11/2018-10/2019

191. Protective levels of anti-pneumococcal polysaccharide 22F and 33F antibodies induced by PCV15 in murine models on invasive and non-invasive pneumococcal disease. CI: Michael E. Pichichero. Sponsor Merck. 11/2018-10/2019

Assessing effect of PCV13 use on incidence of antibiotic-resistant pathogens causing otitis media in children using routine tympanocentesis in outpatient primary care pediatrics. PI: Michael E. Pichichero. Sponsor CDC. 9/30/19-9/29/20